There is no doubt that by the beginning of the third decade of the twenty-first century, medicine had reached an unprecedented level. Surgeons carry out surgeries of amazing complexity, many diseases, from which there was no salvation before, are taken under reliable medical control (such as diabetes mellitus), and a number of diseases have been eradicated completely or only occur in single cases. Among them are such terrible diseases as smallpox and bubonic plague. Numerous conditions, for which there was no more or less effective treatment before, are now absolutely ordinary, easily amenable to therapy. These include, for example, stomach ulcer. Even a century and a half ago, an ordinary cataract blinded a huge number of people, and now you can get rid of it in just fifteen minutes.
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However, despite the fact that in most developed countries medical care is at a high level, one should not forget that at least a relatively high standard of living is observed in a maximum of a quarter of the countries of the world. And, although the efforts of the World Health Organization (WHO) to date are focused mainly on the fight against AIDS, tuberculosis and malaria, diseases such as numerous parasitic infestations have not disappeared anywhere. They affect many hundreds of millions, if not billions of people, mostly in poor, tropical regions. They are caused by helminths, protozoa, as well as bacteria, some viruses and fungi.
In addition to diseases officially recognized by WHO as “neglected”, which include leprosy, Buluri ulcer, leishmaniosis, ascariasis, schistosomiasis and many others, there are a number of diseases that don’t have such a status, but are no less common and dangerous to human health and life. Despite the fact that considerable efforts are being made to eliminate them, they still claim the lives of the population of the poor regions of Africa, Asia and Latin America. Among the most formidable of these diseases are river blindness (onchocerciasis) and lymphatic filariasis, also known as elephantiasis.
It is for the treatment of the last two conditions that a medicine such as Stromectol is used. This name is not too much of a rumor, but Stromectol is a fairly old, well-proven and effective medicine. Most likely, farmers have heard about it, because a drug with the same active ingredient (Ivermectin), only under different trade names, is often used to treat helminthiasis in horses, sheep and cattle.
What Is Stromectol for Humans?
As a veterinary drug, Ivermectin has been used longer than in human medicine. The use of this drug in the treatment of helminthic invasions of humans began in the 1980s, and the drug showed such high efficiency that it became a key tool in the fight against elephantiasis. The program to eradicate this disease, caused by one of the parasitic nematode species, was based on the use of Ivermectin – firstly as a mono-therapy, and later, in 1990s, in a combination with other substances.
To avoid possible confusion, it is important to remember that Stromectol is the same as Ivermectin. More precisely, Stromectol is one of the trade names of the active substance Ivermectin. There are generics (analogues) of Stromectol, sold under other names, but they are completely identical to their prototype in terms of the principle of action, dosage and effect. The only thing that may differ is some excipients that affect the color of the tablet and its density.
In human medicine, Stromectol is used mainly in the form of tablets for oral administration, less often in the form of ointments based on Ivermectin. Tablets in most cases are produced in a dosage of 3 mg each, and ointment creams contain 1% of the active ingredient. You need to store the medicine in a dry, dark place at a temperature not higher than +26°C.
Stromectol Indications for Use
If you live in well-to-do developed countries such as the United States, Canada, and most of Europe, you might think that you don’t need to know what a medicine like Stromectol is used for at all. You are not sitting in a hut in the wilds of Africa or in an Indian bungalow. However, in the mass consciousness, the scale of the prevalence of parasitic diseases, against which drugs like Ivermectin are used, are underestimated. To understand how widely it is used, here is a list of indications for using this medicine:
lymphatic filariasis (elephantiasis) – every year this disease is diagnosed in about 40 million people, almost a billion of the world’s population lives in regions endemic for this disease, and are under constant threat of its development.
river blindness – helminthiasis, affecting, among other organs, the eyes, and often leading to decreased vision and blindness. This disease affects about 20 million people.
Strongyloidiasis – a disease caused by a variety of roundworms that can affect almost any tissue in the body. It affects between 100 and 200 million people in the world.
In addition to these indications, which are the main ones for the use of Stromectol, this drug is also an effective remedy against all types of lice, and it is possible to treat both with oral Ivermectin and in combination with an ointment, or exclusively with an ointment if the volume of lesions is not very large. In addition, Stromectol has proven efficacy against rosacea and blepharitis (inflammation of the eyelids), but only if these conditions are caused by infection with the corresponding microscopic mites.
This medicine is not used in children weighing less than 15 mg. Contraindications for use are renal and hepatic impairment, as well as infection with a large number of Loa Loa worms. This parasite begins to die intensively due to Ivermectin, causing severe toxic reactions in the body.
In principle, most antiparasitic drugs have some degree of neurotoxicity, not because they are toxic in themselves, but because the toxins are secreted by dying parasites. In this regard, the unauthorized use of these drugs is strongly discouraged. If you suspect an infection with a particular parasite, a thorough medical examination, a series of analyses are necessary, and only if there are no contraindications to start treatment. Otherwise, you can accidentally die along with the parasites. And this is not an exaggeration – depression of the central nervous system and ataxia, which can develop with uncontrolled use of the drug, can be fatal to an individual.
This medicine is not suitable for pregnant women. If the mother is breastfeeding, Stromectol is also not recommended. At least ten days should elapse between the end of the medication and the resumption of breastfeeding.
Principle of Stromectol Action
Stromectol affects the nervous system of parasites, causing their paralysis and death. It is important to note that the drug is not effective against all life stages of some parasites.
Stromectol kills parasites due to its selective binding ability and high affinity for glutamate-regulated chlorine channels found in the nerve and muscle cells of invertebrates. In addition, the drug has an anti-inflammatory effect.
Stromectol Treatment Recommendations
The treatment regimen with Stromectol differs depending on which disease needs to be cured.
Stromectol tablets, 3 mg each, are swallowed whole with a glass of water, either on an empty stomach, or 2 hours before or 2 hours after a meal. The dosage and frequency of administration depends on the disease, the patient’s weight (the standard recommendation is 200 micrograms per kilogram of body weight) and the advice of your doctor for your specific case.
In the treatment of strongyloidosis and scabies, a single dose is used in most cases. If this is not enough and the disease does not disappear, after two weeks, a second dose of the drug is prescribed. In the treatment of lymphatic filariasis, a single dose is used, but it is advised to repeat it every 6 or 12 months in order to get rid of all parasites that are in the body at different stages of their development. In case the patient suffers from onchocerciasis, it is also recommended to take this medication two or three times a year. The duration of the use of Stromectol in each patient depends on the doctor’s prescriptions.
Stromectol Side Effects
The most common side effects of Stromectol tablets include transient tachycardia (heart palpitations), flushing, nausea, diarrhea, nausea, vomiting, abdominal pain, itching, skin rash, asthenia (weakness), dizziness, dizziness, drowsiness, dizziness, tremors.
News About Stromectol
Australian scientists from the Royal Hospital in Melbourne and the Institute for the Study of Infection and Immunity. Peter Doherty at the end of 2020 found that Ivermectin, despite the fact that it is an antiparasitic drug, suppresses the SARS-CoV-2 virus (the same famous coronavirus that causes COVID-19 infection) in cell culture – that is, in vitro. Previously, the antiviral activity of Ivermectin has already been demonstrated in vitro, in particular, a phase III clinical study was even conducted, which evaluated the efficacy, safety and feasibility of using this drug in patients with Dengue fever, although the result was unsatisfactory in terms of efficacy.
A single addition of Ivermectin to the medium is sufficient for the number of viral particles in the cell culture in a day, according to PCR data, to decrease by 93% in the supernatant (the liquid part containing the cells) and by 99.8% in the cells. No viruses were detected in the cell culture after 48 and 72 hours. However, there were no signs of toxic cell damage. The probable mechanism of the antiviral action of Ivermectin is the inhibition of the transport of viral proteins into the host cell nucleus, mediated by the IMPα/β1 protein. Based on this, it can be assumed that Ivermectin is an excellent candidate for further research in the field of the treatment of coronavirus. In the case of confirmation of antiviral activity in patients with COVID-19, its early administration can reduce viral load, reduce the severity of the disease and reduce the risk of further spread of infection. The negative results of a clinical study with Dengue fever are not a reason for pessimism – according to the authors, it is caused by viruses from another group (filoviruses), which may respond differently to the use of Ivermectin.
This drug has already been found to be active against a number of viruses, including influenza and human immunodeficiency virus. However, the behavior of the drug when applied to humans is always different from the results obtained in a test tube. This is due to the fact that the human body consists of various systems of organs and tissues, many different cells with different types of receptors, which changes the picture of the action of both Ivermectin and most other drugs.
Stromectol And Malaria
Ivermectin was recently found to be effective against malaria mosquitoes as well. A medical entomologist of Colorado State University has suggested that people receiving Stromectol have high enough blood levels for female malaria mosquitoes to die or become weakened so much that they cannot transmit the causative agent of malaria to another person. The researchers intend to conduct larger trials and hope that Ivermectin will become part of the anti-malaria arsenal, along with insecticide-treated mosquito nets and artemisinin-based combination therapies.
The prospects of the new method are highly appreciated, but it is difficult to implement. In rural areas of poor countries in Africa and Asia, it is difficult to provide the population with doses of the drug every three weeks, which is necessary for the prevention of malaria.
However, malaria-carrying mosquitoes have become resistant to the many drugs that humans have used to control them. It is highly likely that the same will happen with Ivermectin.